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Title   HL - 60 세포의 식작용에 미치는 Retinoic Acid 의 효과 조사를 위한 화학발광 반응의 이용 ( Chemiluminescence Assay for the Monitoring of Phagocytic Activity of HL - 60 Cells Stimulated by Retinoic Acid )
Publicationinfo   1993 Jan; 025(03): 423-429.
Key_word   Retinoic acid, Cell maturation, Phagocytosis, Chemiluminescence
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Abstract   Retinoids were reported that they induced epidermal cell differentiation#. Their stimulating capacity on the cell differentiation can be used for the cancer therapy. This experiment was performed to confirm the potent stimulating effect of the retinoic acid on the cancer cell differentiation by monitoring chemiluminescence. HL-60 cells were stimulated by varing con- centrations of retinoic acid and emitted lights depending on the concentrations. The most ef- fective concentration was IO M, but it had a toxic effect in high concentration(>10(-5)M). These results may iodicate retinoic acid induce the differentiation of HL-60 cell and resulting in the increase of phagocytosis, and therefore the measuring of chemiluminescence can be used to monitor the effect of retinoic acid or other drugs.
저 자   홍은경(Eun Kyung Hong),조영호(Young Ho Cho),서경원(Kyung One Suh),김창규(Chang Gyun Kim),문정조(Jung Jo Mun),이경영(Kyung Yung Lee),김종배(Jong Bae Kim)